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Propylthiouracil (PTU) and methimazole are the two thionamide antithyroid drugs available for use in the United States.

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They could be explained by endocrine disruption and oxidative stress, causing metabolic alterations, depending on dose and exposure time.

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Treatment with methimazole is a form of medical management for hyperthyroidism; it does not cure the condition.

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Propylthiouracil remains the drug of choice in uncommon situations of life-threatening severe thyrotoxicosis (ie, thyroid storm) because of the additional benefit of inhibition of T 4 -to-T 3 conversion.

This results in the intentional development of an underactive thyroid state (hypothyroidism), which is easily, predictably and inexpensively corrected by lifelong daily use of oral thyroid hormone replacement therapy.

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Thyroiditis can cause both thyrotoxicosis (high thyroid hormone levels in the blood) and hypothyroidism (low thyroid hormone levels in the blood).

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